Breakthrough

The spellbinding stories of the scientists whose eureka! breakthroughs in modern physics reveal science's astonishing predictive power. 'An excellent popular science book.' DARA Ó BRIAIN 'A thoroughly informative and entertaining read.' ANNA BURNS , Booker Prize-winning author of Milkman 'One of the best-written books about phsyics I have ever come across.' POPULAR SCIENCE 'Highly entertaining and accessible.' IRISH TIMES 'Fascinating, life enhancing entertainment.' PROSPECT 'Thoroughly enjoyable . . . Chown has done it again.' BBC SKY AT NIGHT Breakthrough takes us on a breathtaking, mind-altering tour of the eureka! moments of modern physics. Charting the spellbinding stories of the scientists who predicted and discovered the existence of unknown planets, black holes, invisible force fields, ripples in the fabric of space-time, unsuspected subatomic particles and even antimatter, Marcus Chown reveals science's greatest mystery: its astonishing predictive power. *** Breakthrough was previously published in 2020 in hardback under the title The Magicians .

The spellbinding stories of the scientists whose eureka! breakthroughs in modern physics reveal science's astonishing predictive power. 'An excellent popular science book.' DARA Ó BRIAIN 'A thoroughly informative and entertaining read.' ANNA BURNS , Booker Prize-winning author of Milkman 'One of the best-written books about phsyics I have ever come across.' POPULAR SCIENCE 'Highly entertaining and accessible.' IRISH TIMES 'Fascinating, life enhancing entertainment.' PROSPECT 'Thoroughly enjoyable . . . Chown has done it again.' BBC SKY AT NIGHT Breakthrough takes us on a breathtaking, mind-altering tour of the eureka! moments of modern physics. Charting the spellbinding stories of the scientists who predicted and discovered the existence of unknown planets, black holes, invisible force fields, ripples in the fabric of space-time, unsuspected subatomic particles and even antimatter, Marcus Chown reveals science's greatest mystery: its astonishing predictive power. *** Breakthrough was previously published in 2020 in hardback under the title The Magicians .

Meet the doctors, scientists and patients patients fighting the world’s worst diseases ‘A must read.’ Siddhartha Mukherjee, bestselling author of The Emperor of All Maladies What does it take to create a new medicine? The trajectory from laboratory to your neighbourhood pharmacy rarely runs smooth. Drug hunting demands radical leaps of imagination, the expertise of many… and a hefty dollop of luck. Unsurprisingly, ‘eureka’ moments come few and far between – but, when they do, they change lives. Charting the discovery of eight revolutionary drugs, Dr William Pao cuts to the innovative heart of biomedical research and celebrates the tireless work of the scientists, doctors, patients and families fighting for better medical care. For each of these medicines, whether a potentially life-saving new treatment for cancer, or something as commonplace as paracetamol, there stands a cast of characters and a wealth of stories. Documenting these fascinating journeys, Breakthrough grants a privileged, behind-the-scenes look at the medicines that improve – and very often save – our lives. Foreword by Nobel Prize-Winner Harold Varmus *** ‘Utterly compelling.’ Dame Kate Bingham, author of The Long Shot ‘A celebration of medical innovation.’ Guardian ‘Captivating... An essential read.’ Art Levinson, former CEO of Genentech

Meet the doctors, scientists and patients patients fighting the world’s worst diseases ‘A must read.’ Siddhartha Mukherjee, bestselling author of The Emperor of All Maladies What does it take to create a new medicine? The trajectory from laboratory to your neighbourhood pharmacy rarely runs smooth. Drug hunting demands radical leaps of imagination, the expertise of many… and a hefty dollop of luck. Unsurprisingly, ‘eureka’ moments come few and far between – but, when they do, they change lives. Charting the discovery of eight revolutionary drugs, Dr William Pao cuts to the innovative heart of biomedical research and celebrates the tireless work of the scientists, doctors, patients and families fighting for better medical care. For each of these medicines, whether a potentially life-saving new treatment for cancer, or something as commonplace as paracetamol, there stands a cast of characters and a wealth of stories. Documenting these fascinating journeys, Breakthrough grants a privileged, behind-the-scenes look at the medicines that improve – and very often save – our lives. Foreword by Nobel Prize-Winner Harold Varmus *** ‘Utterly compelling.’ Dame Kate Bingham, author of The Long Shot ‘A celebration of medical innovation.’ Guardian ‘Captivating... An essential read.’ Art Levinson, former CEO of Genentech

You can live a fulfilling life. Maybe you're reading this because you're nervous you're not living your life in alignment with who you are, it's driving you a little bit mad, and you so desperately want to do something about it. You are not mad. I promise you. You are present. You have a vitality inside you and it's itching to express itself, if only you can get out of your way. And you're not alone -- most of us get mentally trapped, weighed down by childhood and societal programming. Getting out of your way means venturing into the unknown. But this isn't enough. Instead, you need a map, a guide, and some idea of where you're going. I had the same trouble as you. Sometimes I still do. But I figured out a way to walk forward with purpose, meaning, and love in my heart. And so I've written my story, in the hope that it helps you, in some small way, get rid of the nervousness, find alignment, and love the life you're living. In this book, you'll discover: How to look into your life and identify those things that drain your energy and cause you anxiety, fear and emotional sufferingHow to get the courage to let go of and release your suffering and self-sabotageHow to discover the things that give you joy, energy, purpose, clarity and connection in lifeThe hidden benefit to taking responsibility for the things that matter to you, and how you're made for connectionHow to create self improvement and change for personal growth to unleash your creativity and genius (for both women and men)How to design your life simply and effectively, and how to take steps to attain itHow to plan a happy life, do more of what you love, and less of what you hateWhy doing is better than learning, depth is better than breadth, and 90% of everything is noise to remove from your lifeWhy lifestyle design is essential to leading a happy, connected, fulfilled lifeHow auditing others expectations of you, journaling, relationship and responsibility, lifestyle design, and putting a piece of your soul into the things you do; will help you stop the self-sabotage, let go of anxiety and emotional suffering, and plan a happy life full of purpose, love, clarity and connection Do any of these sound like you? A little bit lost and unsure what to doOutwardly 'successful' but inwardly full of anxiety and sufferingYou're on a path but don't know if it's right for youYou want a happy life but can't get the clarity or courage to make a changeYou know you're made for connection but currently feel empty, quietly emotionally sufferingYou're interested in self help and feel you have some healing to do to get back to yourselfYou want to design your life with clarity, on self improvement, on those things you love This book is a vulnerable account of Joe's journey from leaving a path that wasn't his, to designing a life focused on what matters to him, with lessons learned along the way. It helps you rediscover the truth of what you already know, and inspires you to find the courage to act on it.

You can live a fulfilling life. Maybe you're reading this because you're nervous you're not living your life in alignment with who you are, it's driving you a little bit mad, and you so desperately want to do something about it. You are not mad. I promise you. You are present. You have a vitality inside you and it's itching to express itself, if only you can get out of your way. And you're not alone -- most of us get mentally trapped, weighed down by childhood and societal programming. Getting out of your way means venturing into the unknown. But this isn't enough. Instead, you need a map, a guide, and some idea of where you're going. I had the same trouble as you. Sometimes I still do. But I figured out a way to walk forward with purpose, meaning, and love in my heart. And so I've written my story, in the hope that it helps you, in some small way, get rid of the nervousness, find alignment, and love the life you're living. In this book, you'll discover: How to look into your life and identify those things that drain your energy and cause you anxiety, fear and emotional sufferingHow to get the courage to let go of and release your suffering and self-sabotageHow to discover the things that give you joy, energy, purpose, clarity and connection in lifeThe hidden benefit to taking responsibility for the things that matter to you, and how you're made for connectionHow to create self improvement and change for personal growth to unleash your creativity and genius (for both women and men)How to design your life simply and effectively, and how to take steps to attain itHow to plan a happy life, do more of what you love, and less of what you hateWhy doing is better than learning, depth is better than breadth, and 90% of everything is noise to remove from your lifeWhy lifestyle design is essential to leading a happy, connected, fulfilled lifeHow auditing others expectations of you, journaling, relationship and responsibility, lifestyle design, and putting a piece of your soul into the things you do; will help you stop the self-sabotage, let go of anxiety and emotional suffering, and plan a happy life full of purpose, love, clarity and connection Do any of these sound like you? A little bit lost and unsure what to doOutwardly 'successful' but inwardly full of anxiety and sufferingYou're on a path but don't know if it's right for youYou want a happy life but can't get the clarity or courage to make a changeYou know you're made for connection but currently feel empty, quietly emotionally sufferingYou're interested in self help and feel you have some healing to do to get back to yourselfYou want to design your life with clarity, on self improvement, on those things you love This book is a vulnerable account of Joe's journey from leaving a path that wasn't his, to designing a life focused on what matters to him, with lessons learned along the way. It helps you rediscover the truth of what you already know, and inspires you to find the courage to act on it.